4 edition of Potassium ion channels found in the catalog.
Potassium ion channels
Includes bibliographical references and index.
|Statement||edited by Yoshihisa Kurachi, Lily Yeh Jan, Michel Lazdunski.|
|Series||Current topics in membranes -- v. 46.|
|Contributions||Kurachi, Yoshihisa., Jan, Lily Yeh., Lazdunski, Michel.|
|The Physical Object|
|Pagination||xxiv, 492 p. :|
|Number of Pages||492|
Two fundamental concepts about the ion channels of a "resting" neuron are that the channels _____. A) are always open, but the concentration gradients of ions frequently change B) are always closed, but ions move closer to the channels during excitation C) open and close depending on stimuli, and are specific as to which ion can traverse them. Potassium ions are present inside cells in larger amounts than they are outside of cells. The opposite is true for sodium, which is present in higher amounts outside of the cell. As a result, this difference in concentration level between the two electrolytes causes what is known as " membrane potential," which needs to be constantly.
As potassium ion channels break down or the sodium-potassium pump become dysfunctional, it leads to loss of health and adverse changes. Researchers have found that if the diet lacks potassium, then muscle stores of potassium are used to keep the heart’s potassium level and the sodium-potassium pump intact. Pumps and secondary transporters can transport ions at rates approaching several thousand ions per second. Other membrane proteins, ion channels, which are passive transport systems, are capable of ion-transport rates that are more than times as high. These rates of transport through ion channels are close to rates expected for ions diffusing freely through aqueous solution.
Potassium (K +) channels are proteins which span the membrane of cells and which, when open, allow the selective flow of K + ions from one side of the membrane to the other (usually from the inside of the cell to the outside). They can be gated by a variety of stimuli including voltage, changes in intracellular Ca 2+ and certain other physiological mediators. The proteins that function as voltage-gated ion channels have three remarkable properties that enable nerve cells to conduct an electric impulse: (1) opening in response to changes in the membrane potential (voltage gating); (2) subsequent channel closing and inactivation; and (3) like all ion channels, exquisite specificity for those ions that will permeate and those that will not.
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This book is the first to focus on potassium ion channels and covers the recent remarkable progress made in research on these proteins.
Many diseases are caused by the abnormalities of potassium ion channels. They include diabetes mellitus, life-threatening hereditary cardiac arrhythmia, epilepsy, neural degeneration, and renal : $ This book is the first to focus on potassium ion channels and covers the recent remarkable progress made in research on these proteins.
Many diseases are caused by the abnormalities of potassium ion channels. They include diabetes mellitus, life-threatening hereditary cardiac arrhythmia, epilepsy, neural degeneration, and renal Edition: 1.
Book Description. The New Benchmark for Understanding the Latest Developments of Ion Channels. Ion channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli.
Furthermore, potassium ion channels may be a target protein for the research and development of a therapeutic agent for various diseases concerning the lungs, heart, nerves, eyes, and pancreas.
However, there are few books described in detail about potassium ion channels. This book will focus on the characteristics, function and regulation of. Search in this book series.
Potassium Ion Channels Molecular Structure, Function, and Diseases. Edited by Yoshihisa Kurachi, Lily Yeh Jan, Michel Lnzdunski. Vol Pages ii-xxi, () Download full volume. Previous volume. Next volume. Actions for selected chapters. The article reviews the book "Fundamentals of Molecular Physiology of Ion Channels," by M.
Shuba. Ion Channel Reconstitution (Book). Sytkowski, Arthur J. // American Scientist;Sep/Oct87, Vol. 75 Issue 5, p Reviews the book 'Ion Channel Reconstitution,' edited by Christopher Miller. Defining the field of ion channels. Potassium ion channels are essential elements in cellular electrical excitability (Hille, ), while also maintaining a resting potential in non-excitable cells (Miller, ).
Potassium ion channels selectively conduct potassium ions over sodium ions by a factor of (Hille, ). Genes that encode potassium channels are found in.
Ion channels are complex transmembrane proteins which exist in many different forms. It is possible to classify an ion channel using (i) its genetic sequence; (ii) the ion type (sodium, potassium, calcium ) that can pass through the open channel; (iii) its voltage dependence; (iv) its sensitivity to second-messengers such as intra-cellular calcium; (v) its presumed functional role; (vi) its.
The most recently discovered potassium ion channel is KirBac, which makes a total of five potassium ion channels (KcsA, KirBac, KirBac, KvAP, and MthK) with a determined structure. All five are from prokaryotic species. Renal filtration, reabsorption, and excretion. Renal handling of potassium is closely connected to sodium handling.
The 6TM family of K channels comprises the voltage-gated K V subfamilies, the EAG subfamily (which includes hERG channels), the Ca 2+-activated Slo subfamily (actually with 7TM, termed BK) and the Ca 2+-activated SK channels possess a pore-forming α subunit that comprise tetramers of identical subunits (homomeric) or of different subunits (heteromeric).
Leak channels, also called passive channels, are always open, allowing the passage of sodium ions (Na) and potassium ions (K) across the membrane to maintain the resting membrane potential of –70 millivolts.
Voltage-gated ion channels open and close in response to. Cells communicate among themselves by electrical activity. Sophisticated membrane-embedded proteins, called ion channels, catalyze rapid, selective, and regulated ion fluxes across membranes ([Hille, ]).
The resulting membrane currents are responsible for neuronal activity and the systemic. The scorpion toxins are generally considered to block the potassium ion pore, but there is little detailed understanding of their molecular targets.
The third group of toxins targeting potassium ion channels comprises the dendrotoxins isolated from the venoms of three species of African mamba (D.
augusticeps, D. viridis, and D. polylepis). The. ISBN: OCLC Number: Description: xxiv, pages: illustrations ; 24 cm. Contents: Studies of voltage-dependent and inwardly rectifying potassium channels --pt.
e-dependent potassium channels --The impact of the Caenorhabditis elegans genome project on potassium channel biology --Activation of voltage-dependent potassium channels.
13 hours ago Ion channels play key roles in almost all facets of cellular physiology and have emerged as key host cell factors for a multitude of viral infections. A catalogue of ion channel-blocking drugs have been shown to possess antiviral activity, some of which are in widespread human usage for ion channel-related diseases, highlighting new potential for drug repurposing.
Due to the importance of potassium channels in cellular function, researchers have been challenged to develop tools and experimental procedures to probe the function and identify chemicals that modulate the behaviour of this super-family of ion channels. In Potassium Channels: Methods and Protocols, experts in the field present a range of.
Ion movement through channels. The ability of ion channels to select against ions too large is intuitive - the size of the opening in the ion channel simply isn’t big enough for a larger ion to fit through the opening. Potassium, for example, passes through sodium channels rarely.
Unlike most other ion channels, TRP channels are often polymodal, gated by a variety of mechanisms. Furthermore, TRP channels fall into several classes or subtypes based on sequence and structure.
Ion channels and ion pumps are very specific; they allow only certain ions through the cell example, potassium channels will allow only potassium ions through, and the sodium-potassium pump acts only on sodium and potassium ions.
Ion transport proteins have a special role in the nervous systems because voltage-gated ion channels and ion pumps are essential for forming a. The sodium-potassium pump _____. (see book section: Concept Ion pumps and ion channels establish the resting potential of a neuron) expels sodium from the cell expels sodium and potassium from the cell pumps sodium into the cell pumps sodium and potassium into the cell allows ions to move in either direction through the membrane.
Fifth chapter is about potassium channels: there are many different types of the potassium channels (many more than sodium ion channels).
In this chapter, authors have discussed the role of two gap junction proteins—connexins and pannexins—in maintaining the homeostasis of potassium ions, taking cochlea as an example.Get this from a library! Potassium ion channels: molecular structure, function, and diseases. [Yoshihisa Kurachi; Lily Yeh Jan; Michel Lazdunski;] -- This book is the first to focus on potassium ion channels and covers the recent remarkable progress made in research on these proteins.
Many diseases are caused by the abnormalities of potassium ion.Potassium channels constitute a highly diverse class of ion channel and thus participate in multiple modulatory functions. There are several functional types of K⁺ channel, including voltage.